Neuronal Voltage Imaging Services
Voltage imaging enables optical measurement of membrane potential dynamics, providing direct insight into neuronal excitability and fast electrical signaling beyond the temporal resolution of calcium-based methods.
SparkMind offers voltage imaging services primarily based on genetically encoded voltage indicators (GEVIs), supporting functional characterization of neuronal activity in research and early-stage drug discovery programs.
GEVI-Based Voltage Imaging
GEVI-based approaches allow non-invasive, repeatable monitoring of membrane potential changes across neuronal populations, enabling analysis of action potential firing, subthreshold events, and excitability modulation under different experimental conditions.
All-optical electrophysiology with HVI-Cy5 with CheRiff. Liu, S., et al. Nat. Chem. 2021.
Supported Models
- Ion channel or receptor-expressing heterologous cell systems
- Primary rodent neuronal cultures
- Human iPSC-derived neuronal models
- Acute rodent brain slice preparations
- Rodent DRG sensory neuron cultures
Key Readouts & Applications
- Spike frequency and firing pattern analysis
- Membrane potential amplitude and kinetic changes
- Subthreshold depolarization and excitability profiling
- Comparative evaluation of compound-induced effects
- Exploratory functional phenotyping in disease-relevant models
