logo

Patch-Clamp Electrophysiology

Patch Clamp

Home > Neuroscience > Patch-Clamp Electrophysiology

Cellular Electrophysiology & Patch-Clamp Recording

Cellular patch-clamp electrophysiology is a gold-standard technique for directly measuring electrical signaling at the single-cell level. By recording membrane potentials and ionic currents, this approach enables precise characterization of neuronal excitability, ion channel function, and synaptic signaling under both physiological and pathological conditions.

At SparkMind, we provide high-quality cellular electrophysiology services using well-controlled in vitro neuronal models, enabling stable, reproducible, and quantitative patch-clamp recordings from healthy and functionally mature neurons.

Our platform supports whole-cell current-clamp and voltage-clamp recordings across multiple neuron types, bridging molecular mechanisms with cellular function for neuroscience research and early-stage drug discovery.


We routinely perform patch-clamp recordings from the following cellular models:

Primary neurons from rodent brain regions
DRG sensory neurons (rodent)
Human iPSC-derived neurons from donor cells

Applications

  • Functional evaluation of ion channels and receptors in defined neuronal populations
  • Electrophysiological assessment of compound effects on neuronal excitability
  • Disease modeling using DRG and human iPSC-derived neurons
  • Mechanistic studies supporting target validation and lead optimization

Cellular Patch-Clamp Services

A standard cellular patch-clamp workflow includes neuron culture or preparation, electrophysiological stabilization, formation of a high-resistance seal, and whole-cell recordings under current-clamp or voltage-clamp configurations. This approach enables high-resolution functional analysis at the single-cell level.

We provide patch-clamp electrophysiology services for rodent primary neurons, DRG sensory neurons, and human iPSC-derived neuronal models, supporting translational neuroscience and CNS drug discovery programs.

  • Voltage- and ligand-gated ion channel characterization
  • Neuronal excitability profiling under pharmacological modulation
  • Synaptic current analysis in cultured neuronal networks
  • Customized assay design based on experimental goals

上一篇:Acute Brain Slice Electrophysiology

下一篇:已经没有了

Have a project in mind? Contact us anytime!

Back to top